Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation

ABSTRACT Transcription of herpes simplex virus 1 (HSV-1) immediate early (IE) genes is controlled at multiple levels by the cellular transcriptional coactivator, HCF-1. HCF-1 is complexed with epigenetic factors that prevent silencing of the viral genome upon infection, transcription factors that dr...

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Bibliographic Details

Published in:	mBio
Main Authors:	Jesse H. Arbuckle, Jodi L. Vogel, Stacey Efstathiou, Thomas M. Kristie
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-02-01
Subjects:	HCF-1 herpes simplex virus latency HSV reactivation viral chromatin
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03542-22