Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

Abstract The intestinal epithelial receptor Guanylyl Cyclase C (GUCY2C) is a tumor-associated cell surface antigen expressed across gastrointestinal malignancies that can serve as an efficacious target for colorectal cancer immunotherapy. Here, we describe a yeast surface-display approach combined w...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Pragya Rampuria, Lidia Mosyak, Adam R. Root, Kristine Svenson, Michael J. Agostino, Edward R. LaVallie
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-08-01
Online Access:	https://doi.org/10.1038/s41598-023-40467-0