Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

The link between changes in astrocyte function and the pathological progression of Alzheimer's disease (AD) has attracted considerable attention. Interestingly, activated astrocytes in AD show abnormalities in their lipid content and metabolism. In particular, the expression of apolipoprotein E...

Full description

Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	alzheimer’s disease apolipoproteins nuclear receptors/RXR transcription sphingosine phosphate astrocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227524000154