Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host From Viral Infection Through Amplifying Type I Interferon Responses

The metabolite-sensing G protein–coupled receptors (GPCRs) bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. However, the roles of metabolite-sensing GPCRs in viral infection are not well characterized. Here, we identified metabolite-sensi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Qingqing Xiong, Hongjun Huang, Ning Wang, Ruoyu Chen, Naiyang Chen, Honghui Han, Qin Wang, Stefan Siwko, Mingyao Liu, Min Qian, Bing Du
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-10-01
Subjects:	TGR5 ISG metabolite-sensing GPCRs IFN-I viral infection
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02289/full