Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride. Homeostasis of chloride is controlled by two co-transporters, NKCC1 and KCC2. Previous st...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	bumetanide contusion NKCC1 rat spinal cord injury
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.932487/full