Plumbagin, a natural derivative of 1,4-naphthoquinone, induces cyclopic phenomenon via increased apoptosis and ROS generation in the early stage of zebrafish embryos

Plumbagin (PL; 5-hydroxy-2-methyl-1,4-naphthoquinone) is an analogue of juglone (JG) with additional methylation on carbon 2. It has been found in fungi, insects, and plants, especially Malaysian persimmons, and plants containing PL are globally used as folk medicines. Among 1,4-naphthoquinones test...

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Bibliographic Details

Published in:	Ecotoxicology and Environmental Safety
Main Authors:	Yeonju Lim, Chaeeun Kim, Donghyeon Kim, Myoung-Jin Kim, Ji-Woo Yu, Min-Ho Song, Yurim Kim, Junhee Son, Ji-Ho Lee, Sung-Eun Lee
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	1,4-Naphthoquinones Plumbagin Cyclopia Zebrafish embryos Apoptosis ROS generation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651325008802