Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection

Summary: Histone deacetylases (HDACs) are critical immune regulators. However, their roles in interleukin-1β (IL-1β) production remain unclear. By screening 11 zinc-dependent HDACs with chemical inhibitors, we found that HDAC1 inhibitor, 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (D...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	iScience
المؤلفون الرئيسيون:	Jôsimar Dornelas Moreira, Alexei Iakhiaev, Ramakrishna Vankayalapati, Bock-Gie Jung, Buka Samten
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2022-08-01
الموضوعات:	Biochemistry Immunology Microbiology
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2589004222010719