AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions when incorporated. In Jurkat Tag T ly...

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Bibliographic Details

Published in:	mBio
Main Authors:	Balaji Olety, Yoshiko Usami, Yuanfei Wu, Paul Peters, Heinrich Göttlinger
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-02-01
Subjects:	AP-2 CD4 LCK Nef PAK2 SERINC5
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03382-22