Asymmetric synthesis of Heteroatom-bridged [3.2.1]Octane scaffolds via enantioselective β-H elimination reaction
Abstract N-bridged [3.2.1]octanes (tropanes) and their related bridged bicyclic systems constitute highly sought-after scaffolds in drug discovery and development. Notably, the enantioselective synthesis of chiral 3-aryltropanes which are compounds widely distributed across bioactive pharmaceutical...
| Published in: | Nature Communications |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2026-02-01
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| Online Access: | https://doi.org/10.1038/s41467-026-69960-6 |