Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

Abstract We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF: n = 183 (108, 75). Consistent with pr...

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Bibliographic Details

Published in:	npj Parkinson's Disease
Main Authors:	Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41531-025-00949-6