Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo

Abstract In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells on Ctsk deficient stromal cells display reduced colony formation and proliferation, with increase...

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Bibliographic Details

Published in:	Immunity, Inflammation and Disease
Main Authors:	Renate Hausinger, Marianne Hackl, Ana Jardon Alvarez, Miriam Kehr, Sandra Romero Marquez, Franziska Hettler, Christian Kehr, Sandra Grziwok, Christina Schreck, Christian Peschel, Rouzanna Istvánffy, Robert A. J. Oostendorp
Format:	Article
Language:	English
Published:	Wiley 2021-06-01
Subjects:	cathepsin cathepsin K CTSK hematopoietic stem cells lymphopoiesis marrow
Online Access:	https://doi.org/10.1002/iid3.412