SARS-CoV-2 Mpro inhibitor ensitrelvir: asymmetrical cross-resistance with nirmatrelvir and emerging resistance hotspots

SARS-CoV-2 main protease (Mpro) inhibitors are the first-line COVID-19 treatment. Nirmatrelvir is used worldwide, while ensitrelvir, licensed in Japan and Singapore, has received FDA fast-track designation. To facilitate population monitoring for viral resistance and guide next-generation inhibitor...

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Bibliographic Details

Published in:	Emerging Microbes and Infections
Main Authors:	Yuyong Zhou, Karen A. Gammeltoft, Helena D. Tjørnelund-Sjursen, Line A. Ryberg, Anna Offersgaard, Anna Czarnota, Zhe Duan, Long V. Pham, Ulrik Fahnøe, Günther H.J. Peters, Santseharay Ramirez, Jens Bukh, Judith M. Gottwein
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Antiviral resistance SARS-CoV-2 protease inhibitor ensitrelvir nirmatrelvir
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2025.2552716