Piecewise function parameters as responses of the design of experiment in the development of a pulsatile release chronopharmaceutical system

The aim of this work was to develop a pulsatile release system with metoprolol for chronotherapeutical use by coating swellable mini-tablets with Eudragit RS. To study the influence of the formulation factors (amount of coating polymer, plasticizer percentage in film coating and swelling agent perce...

Full description

Bibliographic Details

Published in:	Acta Pharmaceutica
Main Authors:	Vonica-Gligor Andreea Loredana, Tomuţă Ioan, Leucuţa Sorin E.
Format:	Article
Language:	English
Published:	Sciendo 2016-06-01
Subjects:	pulsatile release chronopharmaceutical system piecewise function design of experiment eudragit rs metoprolol
Online Access:	https://doi.org/10.1515/acph-2016-0025