Mitochondrial dysfunction in chromaffin cells from the R6/1 mouse model of Huntington's disease: Impact on exocytosis and calcium current regulation

From a pathogenic perspective, Huntington's disease (HD) is being considered as a synaptopathy. As such, alterations in brain neurotransmitter release occur. As the activity of the sympathoadrenal axis is centrally controlled, deficits in the exocytotic release of catecholamine release may also...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Ana Fernández, Carmen Martínez-Ramírez, Ana Gómez, Antonio M.G. de Diego, Luis Gandía, María José Casarejos, Antonio G. García
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Subjects:	Huntington's disease R6/1 mouse Chromaffin cells Mitochondria Exocytosis Calcium channels
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123000608