Mutations in feline infectious peritonitis virus nonstructural protein 14/16 methyltransferase attenuate the pathogenicity of the virus in cats

ABSTRACT Feline infectious peritonitis virus (FIPV) can cause an immune-mediated disease that is fatal to felines, but there is a lack of clinically effective protection conferred by vaccines. The methyltransferase (MTase) activity of the coronavirus nonstructural proteins nsp14 and nsp16 affects vi...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Zhe Jiao, Jia Li, Pengpeng Wang, Yuanyuan Yan, Lingying Fang, Yuanyuan Chen, Xiaoshuai Hu, Yuejun Shi, Guiqing Peng
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	feline infectious peritonitis virus nsp14 N7-methyltransferase nsp16 2’-O-methyltransferase live attenuated vaccine
Online Access:	https://journals.asm.org/doi/10.1128/jvi.00839-25