Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice

Biallelic variants in the SPG11 gene account for the most common form of autosomal recessive hereditary spastic paraplegia characterized by motor and cognitive impairment, with currently no therapeutic option. We previously observed in a Spg11 knockout mouse that neurodegeneration is associated with...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Neurobiology of Disease
المؤلفون الرئيسيون:	Manon Fortier, Margaux Cauhapé, Suzie Buono, Julien Becker, Alexia Menuet, Julien Branchu, Ivana Ricca, Serena Mero, Karim Dorgham, Khalid-Hamid El Hachimi, Kostantin Dobrenis, Benoit Colsch, Dominic Samaroo, Morgan Devaux, Alexandra Durr, Giovanni Stevanin, Filippo M. Santorelli, Sophie Colombo, Belinda Cowling, Frédéric Darios
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2024-09-01
الموضوعات:	Hereditary spastic paraplegia Motor neuron disease Neurodegeneration Therapy Small molecule Lysosome
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S0969996124001645