Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption

Abstract Background Inflammatory bowel disease (IBD) presents a significant challenge due to its intricate pathogenesis. NSD2, a histone methyltransferase responsible for dimethylating histone 3 at lysine 36, is associated with transcriptional activation. NSD2 expression is decreased in both the int...

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Bibliographic Details

Published in:	Clinical and Translational Medicine
Main Authors:	Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li
Format:	Article
Language:	English
Published:	Wiley 2024-12-01
Subjects:	histone methylation IBD intestinal epithelial homeostasis NSD2 taurine biosynthesis
Online Access:	https://doi.org/10.1002/ctm2.70128