Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans

AimRare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. Sequencing studies in isolated proteinuria suggest that these variants might...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Nicoline Uglebjerg, Fariba Ahmadizar, Dina M. Aly, Marisa Cañadas-Garre, Claire Hill, Annemieke Naber, Asmundur Oddsson, Sunny S. Singh, Laura Smyth, David-Alexandre Trégouët, Layal Chaker, Mohsen Ghanbari, Valgerdur Steinthorsdottir, Emma Ahlqvist, Samy Hadjadj, Mandy Van Hoek, Maryam Kavousi, Amy Jayne McKnight, Eric J. Sijbrands, Kari Stefansson, Matias Simons, Peter Rossing, Tarunveer S. Ahluwalia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	genetics CUBN cubilin kidney function eGFR diabetes
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1081741/full