EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively). Conversely, treatment with C2C12 myotube-conditio...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Britt Hanson, Ioulia Vorobieva, Wenyi Zheng, Mariana Conceição, Yulia Lomonosova, Imre Mäger, Pier Lorenzo Puri, Samir El Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Subjects:	MT: Exploiting Extracellular Vesicles as Therapeutic Agents Special Issue exosomes extracellular vesicles myogenic differentiation Opti-MEM insulin
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253123001786