Clinicopathological and genomic analysis of SWI/SNF chromatin remodeling abnormalities with a focus on SMARCA4 in cancer of unknown primary

Abstract Purpose The estimation of the primary site is crucial when considering chemotherapy regimens in cancer of unknown primary (CUP). The task is particularly challenging for poorly differentiated or undifferentiated carcinoma, or unknown histological tumors with unknown primary (U-CUP). Instead...

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Bibliographic Details

Published in:	Journal of Cancer Research and Clinical Oncology
Main Authors:	Yasutaka Tono, Koshi Sukeno, Akira Tsunoda, Mariko Okayama, Hiroki Oka, Hiroyasu Oda, Kanako Saito, Yoshiki Yamashita, Masayasu Taniguchi, Makoto Ikejiri, Satoshi Tamaru, Masaki Tanabe, Hiroshi Imai, Masatoshi Watanabe, Toshiro Mizuno
Format:	Article
Language:	English
Published:	Springer 2025-08-01
Subjects:	Cancer of unknown primary SMARCA4 SWI/SNF Chromatin remodeling
Online Access:	https://doi.org/10.1007/s00432-025-06293-9