Impact of excessive hypercholesterolemia in pregnancy on the placentas of the male and female offspring

Abstract Excessive hypercholesterolemia (eHC) in pregnancy reduces placental efficiency in both fetal sexes, but the mechanisms are not known. In this study, Sprague Dawley rats received a control or high cholesterol diet (to model eHC) during pregnancy, after which various markers of placental func...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Amanda A. de Oliveira, Angie Stokes, Anita Quon, Murilo E. Graton, Floor Spaans, Christy-Lynn M. Cooke, Sandra T. Davidge
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Hypercholesterolemia in pregnancy Placenta Cholesterol receptors and transporters Unfolded protein response NLRP3 inflammasome
Online Access:	https://doi.org/10.1038/s41598-025-11416-w