Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia

Abstract Acute myeloid leukaemia (AML) is a highly aggressive and devastating malignancy of the bone marrow and blood. For decades, intensive chemotherapy has been the frontline treatment for AML but has yielded only poor patient outcomes as exemplified by a 5-year survival rate of < 30%, even in...

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Bibliographic Details
Published in:Cell Death and Disease
Main Authors: Gus O. Nwosu, David M. Ross, Jason A. Powell, Stuart M. Pitson
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Online Access:https://doi.org/10.1038/s41419-024-06810-7