The Flp type IV pilus operon of Mycobacterium tuberculosis is expressed upon interaction with macrophages and alveolar epithelial cells

The genome of Mycobacterium tuberculosis (Mtb) harbors the genetic machinery for assembly of the Fimbrial low-molecular-weight protein (Flp) type IV pilus. Presumably, the Flp pilus is essential for pathogenesis. However, it remains unclear whether the pili genes are transcribed in culture or during...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Christopher J. Alteri, Nora Rios-Sarabia, Miguel A. De la Cruz, Jorge A. González-y-Merchand, Jorge Soria-Bustos, Carmen Maldonado-Bernal, María L. Cedillo, Jorge A. Yáñez-Santos, Ygnacio Martínez-Laguna, Javier Torres, Richard L. Friedman, Jorge A. Girón, Miguel A. Ares
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	tuberculosis mycobacteria pili adherence virulence biofilms
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.916247/full