Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization

Objective: The aim of the present study was to investigate the effects of targeting the mevalonate pathway (MVP) in rhabdomyosarcoma (RMS), a soft tissue tumor with a prevalence in young people. Methods: In silico analyses of RNA datasets were performed to correlate MVP with RMS patient survival. Th...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Subjects:	Cholesterol Chemoresistance Mevalonate pathway Oxidative stress Rhabdomyosarcoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824002163