Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors

Abstract The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes. Several G-quadruplexes can be formed in the HIV-1 long terminal repeat promoter region and their stabilization results in the inhibition of...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Marcela Pávová, Paul Eduardo Reyes-Gutiérrez, Jaroslav Kozák, Juraj Dobiaš, Yevgen Yurenko, Martin Lepšík, Filip Teplý, Jan Weber
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Online Access:	https://doi.org/10.1038/s41598-023-33263-3