Regioselective and enantioselective propargylic hydroxylations catalyzed by P450tol monooxygenases

Abstract Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts. Here a green and efficient asymmetric hydroxylation of primary and secondary C–H bonds at propargylic positions has been established. A series of optically a...

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Bibliographic Details

Published in:	Bioresources and Bioprocessing
Main Authors:	Xu Deng, Cheng-Cheng Song, Wen-Jing Gu, Yu-Jie Wang, Lu Feng, Xiao-Jian Zhou, Ming-Qiang Zhou, Wei-Cheng Yuan, Yong-Zheng Chen
Format:	Article
Language:	English
Published:	SpringerOpen 2024-07-01
Subjects:	Biocatalysis Hydroxylation P450 monooxygenase Propargylic alcohols Enantioselectivity
Online Access:	https://doi.org/10.1186/s40643-024-00771-7