Maternal Metformin Administration During the Pre-Gestation Period Improves Transient Cerebral Ischemia Injury in Male Offspring Rats

Purpose: It seems that maternal intervention, which may involve epigenetic mechanisms, can affect cerebral ischemia in offspring. Metformin consumption by the mother activates the AMP-activated protein kinase (AMPK) pathway. Metformin has also induced the AMPK and protected neurons in cerebral ische...

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Bibliographic Details

Published in:	Advanced Pharmaceutical Bulletin
Main Authors:	Reyhaneh Vaali, Iraj Ahmadi, Fradin Sehati, Mina Ranjbaran, Marjan Nikbakhtzadeh, Fatemeh Nabavizadeh, Abbas Zareei, Ghorbangol Ashabi
Format:	Article
Language:	English
Published:	Tabriz University of Medical Sciences 2024-12-01
Subjects:	metformin ischemia memory offspring ampk rats
Online Access:	https://apb.tbzmed.ac.ir/PDF/apb-14-927.pdf