Comparative membrane lipidomics of hepatocellular carcinoma cells reveals diacylglycerol and ceramide as key regulators of Wnt/β‐catenin signaling and tumor growth

Hepatocellular carcinoma (HCC) is largely associated with aberrant activation of Wnt/β‐catenin signaling. Nevertheless, how membrane lipid composition is altered in HCC cells with abnormal Wnt signaling remains elusive. Here, by exploiting comprehensive lipidome profiling, we unravel the membrane li...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Yagmur Azbazdar, Yeliz Demirci, Guillaume Heger, Dogac Ipekgil, Mustafa Karabicici, Gunes Ozhan
Format:	Article
Language:	English
Published:	Wiley 2023-11-01
Subjects:	ceramide comparative lipidome profiling diacylglycerol hepatocellular carcinoma plasma membrane Wnt/β‐catenin pathway
Online Access:	https://doi.org/10.1002/1878-0261.13520