Mycobacterial ESAT-6 triggers cGAS-STING pathway via the GSDMD-NT dependent mitochondria dysfunction

Mycobacterium tuberculosis (Mtb) remains a global health threat due to its ability to subvert host immune responses. Emerging evidence suggests that Mtb infection induces the production of type I interferons (IFNs), during which cGAS directly binds to Mtb genomic DNA. Here, we demonstrate that ESAT-...

詳細記述

書誌詳細

出版年:	Virulence
主要な著者:	Yang Yang, Jinxia Xu, Yanping Hu, Xinxin Zang, Yunjie Li, Ahui Xu, Hexiang Jiang, Jingyan Fan, Luqing Cui, Bei Huang, Fushan Shi, Houhui Song
フォーマット:	論文
言語:	英語
出版事項:	Taylor & Francis Group 2025-12-01
主題:	Mtb ESAT-6 cGAS/STING mitochondria damage GSDMD
オンライン･アクセス:	https://www.tandfonline.com/doi/10.1080/21505594.2025.2570001