In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells

Abstract I-Motifs (iM) are non-canonical DNA structures potentially forming in the accessible, single-stranded, cytosine-rich genomic regions with regulatory roles. Chromatin, protein interactions, and intracellular properties seem to govern iM formation at sites with i-motif formation propensity (i...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Šimon Džatko, Tomáš Loja, Martina Lenarčič Živković, Riccardo Rigo, Roberto El-Khoury, Israel Serrano-Chacón, Masad J. Damha, Carlos González, Jean-Louis Mergny, Silvie Foldynová-Trantírková, Lukáš Trantírek
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Online Access:	https://doi.org/10.1038/s41467-024-46221-y