Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity

Antigen presentation by major histocompatibility complex class I (MHC-I) is crucial for T cell–mediated killing, and aberrant surface MHC-I expression is tightly associated with immune evasion. To address MHC-I downregulation, we conducted a high-throughput flow cytometry screen, identifying bleomyc...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Qian Yu, Yu Dong, Xiaobo Wang, Chenxuan Su, Runkai Zhang, Wei Xu, Shuai Jiang, Yongjun Dang, Wei Jiang
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2024-09-01
Subjects:	Oncology
Online Access:	https://doi.org/10.1172/jci.insight.177788