Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition

Abstract Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their mechanism of action is not well understood. Decoding the mechanisms used by individual T cells can help improve the efficacy of T cells while also identifying mechanisms of T cell failure leading to tumor es...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Melisa J. Montalvo, Irfan N. Bandey, Ali Rezvan, Kwan-Ling Wu, Arash Saeedi, Rohan Kulkarni, Yongshuai Li, Xingyue An, K M Samiur Rahman Sefat, Navin Varadarajan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-02-01
Online Access:	https://doi.org/10.1038/s41419-024-06461-8