Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics

Abstract Backgrounds Atherosclerosis is a major contributor to cardiovascular diseases worldwide. Despite advancements in understanding its pathology, significant gaps remain in the molecular characterization of atherosclerotic plaques. This study addresses this gap by extensively profiling the prot...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun, Zhichao Lai
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Carotid artery stenosis Atherosclerosis Proteomics Mendelian randomization Therapeutic targets
Online Access:	https://doi.org/10.1186/s12916-025-04058-2