Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease

Abstract The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pathway increases the OCA treatment response rate. The hepatic transcriptome and bil...

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Bibliographic Details

Published in:	Biology Direct
Main Authors:	Seung Min Lee, Dae Won Jun, Eileen Laurel Yoon, Ju Hee Oh, Yoon Jin Roh, Eun Jeoung Lee, Ji-Hee Shin, Young-Do Nam, Hyun Sung Kim
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Non-alcoholic fatty liver Obeticholic acid Bile acid Alternative pathway Biomarker Microbiome
Online Access:	https://doi.org/10.1186/s13062-023-00407-4