Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers. Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transduce...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-11-01
Online Access:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001721&type=printable