Tachyplesin Causes Membrane Instability That Kills Multidrug-Resistant Bacteria by Inhibiting the 3-Ketoacyl Carrier Protein Reductase FabG

Tachyplesin is a type of cationic β-hairpin antimicrobial peptide discovered in horseshoe crab approximately 30 years ago that is well known for both its potential antimicrobial activities against multidrug-resistant bacteria and its cytotoxicity to mammalian cells. Though its physical interactions...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Cunbao Liu, Jialong Qi, Bin Shan, Yanbing Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Subjects:	tachyplesin FabG unsaturated fatty acids membrane rupture multidrug-resistant bacteria cytotoxicity
Online Access:	http://journal.frontiersin.org/article/10.3389/fmicb.2018.00825/full