Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking

Abstract Macrocyclic peptides represent an attractive drug modality due to their favourable properties and amenability to in vitro evolution techniques such as phage or mRNA display. Although very powerful, these technologies are not without limitations. In this work, we address some of their drawba...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Sara Linciano, Ylenia Mazzocato, Zhanna Romanyuk, Filippo Vascon, Lluc Farrera-Soler, Edward Will, Yuyu Xing, Shiyu Chen, Yoichi Kumada, Marta Simeoni, Alessandro Scarso, Laura Cendron, Christian Heinis, Alessandro Angelini
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Online Access:	https://doi.org/10.1038/s41467-025-60907-x