The Novel Diketopiperazine Derivative, Compound 5-3, Selectively Inhibited the Proliferation of FLT3-ITD Mutant Acute Myeloid Leukemia (AML) Cells

The internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) is associated with high recurrence and mortality rates in acute myeloid leukemia (AML), making it a critical target for anti-AML therapies. Plinabulin is a diketopiperazines derivative that exhibits extensive anti-canc...

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Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Shijie Bi, Yating Cao, Shiyuan Fang, Yanyan Chu, Zixuan Zhang, Meng Li, Rilei Yu, Jinbo Yang, Yu Tang, Peiju Qiu
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Subjects:	acute myeloid leukemia FLT3-ITD mutation diketopiperazine tubulin
Online Access:	https://www.mdpi.com/1660-3397/23/7/289