Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity

ObjectiveRegulatory T cells (Tregs) play a pivotal role in tumor immune evasion, and strategies to overcome their immunosuppressive activity are urgently needed. This study investigates the immunomodulatory effects of microwave ablation (MWA) on TNFRSF4+ Tregs, focusing on the OX40L/TNFRSF4 signalin...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Runqi Guo, Yufeng Wang, Jie Sun, Yuanming Li, Zhixin Bie, Xiaoguang Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	microwave ablation TNFRSF4+ Treg tumor immunosuppression tumor microenvironment CD8+ T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637317/full