Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity

ObjectiveRegulatory T cells (Tregs) play a pivotal role in tumor immune evasion, and strategies to overcome their immunosuppressive activity are urgently needed. This study investigates the immunomodulatory effects of microwave ablation (MWA) on TNFRSF4+ Tregs, focusing on the OX40L/TNFRSF4 signalin...

书目详细资料
发表在:	Frontiers in Immunology
Main Authors:	Runqi Guo, Yufeng Wang, Jie Sun, Yuanming Li, Zhixin Bie, Xiaoguang Li
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2025-10-01
主题:	microwave ablation TNFRSF4+ Treg tumor immunosuppression tumor microenvironment CD8+ T cells
在线阅读:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637317/full

相似书籍

Inhibiting interferon-γ induced cancer intrinsic TNFRSF14 elevation restrains the malignant progression of glioblastoma
由: Yunhe Han, et al.
出版: (2024-07-01)

麝鼠TNFRSF13C和TNFRSF4基因表达分析
由: 廖光珍, et al.
出版: (2020-01-01)

BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT
由: Sabrina N. Copsel, et al.
出版: (2019-01-01)

TNFRSF12A expression in stomach adenocarcinoma and its preliminary role in predicting immunotherapy response
由: Lin-De Sun, et al.
出版: (2025-05-01)

Editorial: Inflammatory Treg reprogramming in the tumor immune microenvironment
由: Xinpei Deng, et al.
出版: (2024-04-01)

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
由: Christina M. Paluskievicz, et al.
出版: (2019-10-01)

Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation
由: Jinchao Zhao, et al.
出版: (2025-10-01)

Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy
由: Zhaokai Zhou, et al.
出版: (2024-09-01)

Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments
由: Xiang Li, et al.
出版: (2024-01-01)

Tregs are involved in VEGFA/ VASH1-related angiogenesis pathway in ovarian cancer
由: Sijing Qiao, et al.
出版: (2023-06-01)

TNFRSF10C methylation is a new epigenetic biomarker for colorectal cancer
由: Cong Zhou, et al.
出版: (2018-09-01)

M2 macrophage facilitated angiogenesis in cutaneous squamous cell carcinoma via circ_TNFRSF21/miR‐3619‐5p/ROCK axis
由: Jun Ma, et al.
出版: (2022-08-01)

Tnfrsf1b Protects Zebrafish Against Klebsiella pneumoniae Infection
由: Jing Y, et al.
出版: (2025-10-01)

Integrated Single‐Cell RNA‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer
由: Dongwei Li, et al.
出版: (2025-09-01)

Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives
由: Farhad Seif, et al.
出版: (2023-03-01)

Erythroblasts Promote the Development of a Suppressive Lymphocyte Phenotype via Treg Induction and PD1 Upregulation on the Surfaces of B-Cells: A Study on the Subpopulation-Specific Features of Erythroblasts
由: Kirill Nazarov, et al.
出版: (2025-07-01)

Purcutaneus Radiofrequency Ablation In Liver Tumor
由: Budi Tulaka, et al.
出版: (2022-09-01)

TNFRSF11B promotes the progression of bladder cancer through PI3K/AKT signaling pathway
由: Hao Deng, et al.
出版: (2024-12-01)

Association of TNFRSF19 with a TNF family-based prognostic model and subtypes in gliomas using machine learning
由: Youwei Guo, et al.
出版: (2024-04-01)

Integrated Transcriptome Analyses and Experimental Verifications of Mesenchymal-Associated TNFRSF1A as a Diagnostic and Prognostic Biomarker in Gliomas
由: Biao Yang, et al.
出版: (2020-03-01)

Circulating CD4<sup>+</sup> Treg, CD8<sup>+</sup> Treg, and CD3<sup>+</sup> γδ T Cell Subpopulations in Ovarian Cancer
由: Rong Li, et al.
出版: (2023-01-01)

TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS
由: Sinem Fırtına, et al.
出版: (2023-10-01)

Predicting TNFRSF4 expression and prognosis in head and neck squamous cell carcinoma tissue: a pathological image analysis approach
由: Weiming Chu, et al.
出版: (2024-12-01)

A Null Mutation of TNFRSF11A Causes Dysosteosclerosis, Not Osteopetrosis
由: Tarık Kırkgöz, et al.
出版: (2022-06-01)

CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype
由: Binle Tian, et al.
出版: (2025-04-01)

TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity
由: Mina Ding, et al.
出版: (2025-05-01)

Fragile Treg cells: Traitors in immune homeostasis?
由: Xiyu Song, et al.
出版: (2024-08-01)

Exosome-Mediated Immunosuppression in Tumor Microenvironments
由: Qi-Hui Xie, et al.
出版: (2022-06-01)

Juvenile Paget disease with unique compound heterozygous sequence variants in the TNFRSF11B gene
由: Jana Horackova, et al.
出版: (2025-08-01)

A rare missense p.C125Y mutation in the TNFRSF1A gene identified in a Chinese family with tumor necrosis factor receptor-associated periodic fever syndrome
由: Mengqing Qian, et al.
出版: (2024-06-01)

Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB signaling axis
由: Canhui Cao, et al.
出版: (2025-08-01)

Clinical and functional characterization of a novel TNFRSF9 variant causing immune dysregulation with predisposition to EBV-driven lymphomagenesis
由: Peiwei Zhao, et al.
出版: (2025-08-01)

Navigating the immunosuppressive brain tumor microenvironment using spatial biology
由: Samuel S. Widodo, et al.
出版: (2024-09-01)

ANKRD2 expression combined with TNFRSF19 expression for evaluating the prognosis of oral squamous cell carcinoma patients
由: Shucong Yao, et al.
出版: (2024-01-01)

25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis
由: Mengting He, et al.
出版: (2024-04-01)

Single‐cell transcriptomics identify TNFRSF1B as a novel T‐cell exhaustion marker for ovarian cancer
由: Yan Gao, et al.
出版: (2023-09-01)

Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation
由: Yumchinserchin Narangerel, et al.
出版: (2024-03-01)

Costimulation blockade and Tregs in solid organ transplantation
由: Moritz Muckenhuber, et al.
出版: (2022-09-01)

Identification of radiation-sensitive genes as biomarkers for biodosimetry: an ex vivo analysis of TNFRSF10B, ZMAT3, POLH, and PLK2 in human blood samples
由: Mahsa Boogari, et al.
出版: (2025-10-01)

LFA-1 knockout inhibited the tumor growth and is correlated with treg cells
由: Ting Niu, et al.
出版: (2023-09-01)