The Methyl-CpG-Binding Protein Mbd2 Regulates Susceptibility to Experimental Colitis via Control of CD11c+ Cells and Colonic Epithelium

Methyl-CpG-binding domain-2 (Mbd2) acts as an epigenetic regulator of gene expression, by linking DNA methylation to repressive chromatin structure. Although Mbd2 is widely expressed in gastrointestinal immune cells and is implicated in regulating intestinal cancer, anti-helminth responses and colon...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Gareth-Rhys Jones, Sheila L. Brown, Alexander T. Phythian-Adams, Alasdair C. Ivens, Peter C. Cook, Andrew S. MacDonald
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-02-01
Subjects:	epigenetics colitis macrophage epithelium dendritic cell
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00183/full