PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications

Abstract The clinical complex called metabolic syndrome (MetS) is caused by the interaction of genetic and cardiovascular risk factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to MetS. This study aimed to evaluate how PDIA3 po...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Man Zheng, Yeting Li, Lei Gu, Chunyan Xiang, Xiaoning Li, Shanshan Li, Nannan Li, Hongtao Lan, Fenglei Zhang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	Metabolic syndrome PDIA3 Single nucleotide polymorphism Antihypertensive treatment
Online Access:	https://doi.org/10.1038/s41598-025-15075-9