Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments

Purpose: RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific antibody denosumab, [⁸⁹Zr]Zr...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Jonatan Dewulf, Ivanna Hrynchak, Sarah Geudens, Isabel Pintelon, Christel Vangestel, José Sereno, Peter A. van Dam, Antero J. Abrunhosa, Filipe Elvas, Tim Van den Wyngaert
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Subjects:	RANKL antibody Fab fragment tumor imaging immuno-PET
Online Access:	https://www.mdpi.com/1999-4923/14/5/939