STC3141 improves acute lung injury through neutralizing circulating histone in rat with experimentally-induced acute respiratory distress syndrome

Background: Acute respiratory distress syndrome (ARDS) remains a challenge because of its high morbidity and mortality. Circulation histones levels in ARDS patients were correlated to disease severity and mortality. This study examined the impact of histone neutralization in a rat model of acute lun...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yangyang Ge, Chenchen Wang, Chenye Yao, Yong Wang, Yuduo Zheng, Junjie Luo, Jiayi Chen, Yu Wang, Fuquan Wang, Li Wang, Yun Lin, Lin Shi, Shanglong Yao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	ARDS ALI histone STC3141 histone neutralization
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1166814/full