METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy

Purpose To explore the N6-methyladenosine (m6A) modification mechanism of taurine upregulated gene 1 (TUG1) and whether methyltransferase 3 (METTL3) can promote peroxisome proliferators-activated receptor γ coactivator 1 alpha (PGC-1α) transcription and alleviate mitochondrial dysfunction.Methods In...

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Bibliographic Details

Published in:	Renal Failure
Main Authors:	Tong Chen, Juan Wang, Yanyan Xu, Yonghong Zhu, Ying Jin, Qiuling Fan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Diabetic nephropathy m6A modification METTL3 lncRNA TUG1 mitochondria
Online Access:	https://www.tandfonline.com/doi/10.1080/0886022X.2025.2521455