Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment

Although some cohort studies have indicated a close association between diabetes and HCC, the underlying mechanism about the contribution of diabetes to HCC progression remains largely unknown. In the study, we applied a novel HCC model in SD rat with diabetes and a series of high glucose-stimulated...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Diabetes mellitus Hepatocellular carcinoma Pyruvate kinase M2 Thioredoxin Chemerin
Online Access:	http://www.sciencedirect.com/science/article/pii/S221323172400079X