Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of Axin is counteracted through relocalization of Axin...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Marinella G Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N Sandoval, Peter S Liu, Sheila Bheddah, Janet Tao, Jennie R Lill, Jo-Anne Hongo, David Davis, Donald S Kirkpatrick, Paul Polakis, Mike Costa
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3143158?pdf=render