The senolytic drug ABT-263 accelerates ovarian aging in older female mice

Abstract Previous studies have reported that senolytic drugs can reverse obesity-mediated accumulation of senescent cells in the ovary and protect against cisplatin-induced ovarian injury by removing senescent cells. Early intervention with ABT-263 has been shown to mitigate ovarian aging. However,...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Xiyang Xia, Yingying Yang, Pengfei Liu, Li Chen, Xiuliang Dai, Pingping Xue, Yufeng Wang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	Reproductively old females Ovarian aging Senolytic drug Ovarian reserve Multinucleated giant cells Ovarian fibrosis
Online Access:	https://doi.org/10.1038/s41598-024-73828-4