The release of host-derived antibodies bound to the variant surface glycoprotein (VSG) of Trypanosoma brucei cannot be explained by pH-dependent conformational changes of the VSG dimer [version 1; peer review: 2 approved]

Background Trypanosoma brucei is a protozoan parasite that evades the mammalian host’s adaptive immune response by antigenic variation of the highly immunogenic variant surface glycoprotein (VSG). VSGs form a dense surface coat that is constantly recycled through the endosomal system. Bound antibodi...

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Bibliographic Details

Published in:	Open Research Europe
Main Authors:	Pavel Nesterov, Patrick Eirich, Ekaterina V. Skorb, Sergey Shityakov, Jens Broscheit, Bodo Sander, Nicola G. Jones, Thomas Dandekar, Markus Engstler
Format:	Article
Language:	English
Published:	F1000 Research Ltd 2024-04-01
Subjects:	Trypanosoma brucei variant surface glycoprotein molecular dynamics conformational shift epitopes eng
Online Access:	https://open-research-europe.ec.europa.eu/articles/4-87/v1