Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. Familial cases of PD are often caused by mutations of PTEN-induced kinase 1 (PINK1) and the ubiquitin ligase Parkin, both pivotal in maintaining mitochondrial quality co...

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الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Sara Bitar, Timo Baumann, Christopher Weber, Majd Abusaada, Liliana Rojas-Charry, Patrick Ziegler, Thomas Schettgen, Isabella Eva Randerath, Vivek Venkataramani, Bernhard Michalke, Eva-Maria Hanschmann, Giuseppe Arena, Rejko Krueger, Li Zhang, Axel Methner
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2024-08-01
الموضوعات:	mitochondria Parkinson's disease dopaminergic neurons oxidative distress Drosophila iron
الوصول للمادة أونلاين:	https://elifesciences.org/articles/97027